[Toyohashi University of Technology] Simulation-Guided Search Uncovers Two Promising TB Drug Candidates Targeting CYP

29 May 2026

Toyohashi University of Technology news release 

A research team led by Associate Professor Noriyuki Kurita from the Department of Computer Science and Engineering at Toyohashi University of Technology and by Associate Professor Pornpan Pungpo from Ubon Ratchathani University in Thailand has proposed a novel therapeutic TB agent, using high-precision molecular simulation techniques.

The proposed drug is anticipated to bind strongly to the drug-metabolizing enzyme cytochrome P450 (CYP), thereby inhibiting excessive CYP-mediated metabolism and preventing the degradation of co-administered drugs.

Additionally, because this agent targets enzymes released by the TB bacterium rather than the bacterium itself, the likelihood of bacterial mutation and resistance development is reduced, suggesting sustained therapeutic efficacy over an extended period.

Read the full news release here.

Source: Medical Xpress