The Rockefeller University: A New Method Reveals Hidden Rules of Gene Control
4 March 2026
The Rockefeller University news story
Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, revealing transcription drivers by reconstructing transcription outside of the cell.
This approach, described in a paper published in Molecular Cell, focuses squarely on how the enzyme that copies DNA into RNA operates to allow unique insight into how genes are switched on and how RNA synthesis begins and ends. Researchers used this method to reveal fundamental features of the transcription cycle — the process by which cells copy DNA into RNA to make proteins — in Mycobacterium tuberculosis (Mtb). The findings may help scientists better understand this pathogen, as well as the drugs designed to combat it.
Read the full news story here.
Source: Newswise
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